Chemical Name: 3,3'-[(1,1'-Biphenyl)-4,4'-diyl-bis(2,1-diazenediyl)]bis(4-amino-1-naphthalenesulfonic acid) disodium salt
Biological ActivityVGlut inhibitor; decreases synaptic transmission in the dentate gyrus. Also an amyloid fibril-binding dye; inhibits Fib-beta A neurotoxicity by inhibiting fibril formation or by binding to preformed fibrils. Also inhibits the pancreatic islet cell toxicity of diabetes-associated amylin. Excitation wavelength is 497 nm.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.
Lorenzo et al.
Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors.
Neale et al.
Effect of VGLUT inhibitors on glutamatergic synaptic transmission in the rodent hippocampus and prefrontal cortex.
Neale et al.
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