Catalog Number: 1399
Chemical Name: N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1 pentanamine hydrochloride
Biological Activity
Potent, non-peptide KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC50 ~ 200 nM). Inhibits KV1.4 with an IC50 of ~ 300 nM. Selective over KV1.1, KV1.2, KV1.5, KV1.6, KV3.1-4, and KV4.2.
Technical Data
  • M.Wt:
    340.89
  • Formula:
    C21H24N2.HCl
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    478341-55-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated.
    Jager et al.
    J.Physiol., 1998;506:291
  2. Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation.
    Nguyen et al.
    Mol.Pharmacol., 1996;50:1672
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CP 339818 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Kv1 channels and neural processing in vestibular calyx afferents.
    Authors: Meredith Et al.
    J Neurosci 2015;9:85

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