Potent, non-peptide KV
1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC50
~ 200 nM). Inhibits KV
1.4 with an IC50
of ~ 300 nM. Selective over KV
3.1-4, and KV
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated.
Jager et al.
Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation.
Nguyen et al.
The citations listed below are publications that use Tocris products. Selected citations for CP 339818 hydrochloride include:
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