Chemical Name: (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron
Biological ActivityNear-infrared probe that binds to Aβ40 aggregates (Kd = 38 nM) and elicits an emission blue shift. Shown to bind to plaques in APP-PS1 transgenic mice, in vitro. Detects senile plaques in 19-month-old Tg2576 mice in vivo. Penetrates the blood-brain barrier.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits.
Ran et al.
Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species.
Ran et al.
PLoS One., 2011;6:e19362
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