Catalog # Availability Size / Price Qty
CRANAD 2 | CAS No. 1193447-34-5 | Fluorescent Amyloid B Probes
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Description: Near-infrared probe that detects Aβ40 aggregates. Used for: amyloid-β detection in vitro and in vivo. Application: fluorescence microscopy, epifluorescence microscopy

Chemical Name: (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron

Purity: ≥98%

Product Details

Biological Activity

Key information: CRANAD 2 is a curcumin derivatized near-infrared probe that binds to Aβ40 aggregates. Penetrates the blood-brain barrier.

Used for: amyloid- detection in vitro, tissue and in vivo. Shown to bind to plaques in APP-PS1 transgenic mice, in vitro. Detects senile plaques in 19-month-old Tg2576 mice in vivo.

Application: Fluorescence microscopy, epifluorescence microscopy.

Properties and Photophysical Data: CRANAD 2 binds to Aβ40 aggregates (Kd = 38 nM) and elicits upon interacting with Aβ aggregates, an emission blue shift (from 805 nm to 715 nm). When unbound in PBS, excitation and emission maxima (λ) are 640 nm and 805 nm, respectively.

Technical Data

Soluble to 5 mM in DMSO with gentle warming
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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