Catalog Number: 4803
Chemical Name: (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron
Biological Activity
Near-infrared probe that binds to Aβ40 aggregates (Kd = 38 nM) and elicits an emission blue shift. Shown to bind to plaques in APP-PS1 transgenic mice, in vitro. Detects senile plaques in 19-month-old Tg2576 mice in vivo. Penetrates the blood-brain barrier.
Technical Data
  • M.Wt:
    410.26
  • Formula:
    C23H25BF2N2O2
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1193447-34-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits.
    Ran et al.
    J.Am.Chem.Soc., 2009;131:15257
  2. Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species.
    Ran et al.
    PLoS One., 2011;6:e19362

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