Endogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED50
values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related peptide (CGRP) and adrenomedullin receptors. Inhibits formation of multinuclear osteoclasts with similar efficacy to CT in vitro
. Suppresses food intake and increases body temperature in free-feeding rats, and significantly decreases plasma calcium levels in vivo
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Central effects of calcitonin receptor-stimulating peptide-1 on energy homeostasis in rats.
Sawada et al.
A novel member of the calcitonin gene-related peptide family, calcitonin receptor-stimulating peptide, inhibits the formation and activity of osteoclasts.
Notoya et al.
Calcitonin receptor-stimulating peptide, a new member of the calcitonin gene-related peptide family. Its isolation from porcine brain, structure, tissue distribution, and biological activity.
Katafuchi et al.