CW 008

Tocris Bioscience | Catalog # 5495

PKA signaling activator; promotes osteogenesis from hMSCs
Tocris Bioscience
Discontinued Product
5495 has been discontinued. View all Protein Kinase A Activators products.

Key Product Details

Description

PKA signaling activator; promotes osteogenesis from hMSCs
View all Protein Kinase A Activators »

Product Description

CW 008 is a cAMP/PKA/CREB pathway activator. Promotes osteogenic differentiation of human bone marrow-derived MSCs in vitro. Increases bone mass and bone volume density in ovariectomized mice.

Product Specifications for CW 008

Molecular Weight

420.37

Formula

C21H14F2N6O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide

CAS Number

1134613-19-6

PubChem ID

59528098

InChI Key

KCIMKTNQCUDTFI-UHFFFAOYSA-N

SMILES

O=C(C1=CC=C(F)C=C1)NC2=NNC3=NC(C4=C5N(C=CC(OC)=C5)N=C4)=C(F)C=C32

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.02 50

Preparing Stock Solutions for CW 008

The following data is based on the product molecular weight 420.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.76 mL 23.79 mL 47.58 mL
2.5 mM 0.95 mL 4.76 mL 9.52 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
25 mM 0.10 mL 0.48 mL 0.95 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for CW 008

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CW 008

For research use only

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