D-erythro-Sphingosine (synthetic) (CAS 123-78-4): R&D Systems
Catalog Number: 0633
Chemical Name: trans-D-erythro-2-Amino-4-octadecene-1,3-diol
Biological Activity
Inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.
Technical Data
  • M.Wt:
    299.5
  • Formula:
    C18H37NO2
  • Solubility:
    Soluble to 5 mM in DMSO and to 50 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
    123-78-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Sphingosine inhibition and promotion of histamine release from isolated rat mast cells.
    Grossman
    Agents Actions, 1990;31:171
  2. Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds.
    Merrill et al.
    Biochemistry, 1989;28:3138

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