Inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.
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All Tocris products are intended for laboratory research use only.
Sphingosine inhibition and promotion of histamine release from isolated rat mast cells.
Agents Actions, 1990;31:171
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds.
Merrill et al.