Catalog Number: 3422
Biological Activity
Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.
Technical Data
  • M.Wt:
    1610.9
  • Formula:
    C75H114N22O18
  • Sequence:
    XQRLGNQWAVGFLL

    (Modifications: X = Glp, Phe-12 = D-Phe, Leu-14 = C-terminal amide)

  • Solubility:
    Soluble to 10 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    108437-88-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. [d-Phe12]bombesin analogues: a new class of bombesin receptor antagonists.
    Heinz-Erian et al.
    Am.J.Physiol., 1987;252:G439
  2. (d-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists.
    Merali et al.
    Synapse, 1988;2:282
  3. Bombesin receptor antagonists block the effects of exogenous bombesin but not of nutrients on food intake.
    Flynn
    Physiol.Behav., 1997;62:791

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