Biological Activity[D-Phe12,Leu14]-Bombesin is a bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.
(Modifications: X = Glp, Phe-12 = D-Phe, Leu-14 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
[d-Phe12]bombesin analogues: a new class of bombesin receptor antagonists.
Heinz-Erian et al.
(d-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists.
Merali et al.
Bombesin receptor antagonists block the effects of exogenous bombesin but not of nutrients on food intake.
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