Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50
value of 2 μ
M. Inhibits amylase release in vitro
= 4 μ
M) and attenuates bombesin-mediated suppression of food intake in vivo
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[d-Phe12]bombesin analogues: a new class of bombesin receptor antagonists.
Heinz-Erian et al.
(d-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists.
Merali et al.
Bombesin receptor antagonists block the effects of exogenous bombesin but not of nutrients on food intake.