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(D)-PPA 1

Catalog #: 6515 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6515/1
(D)-PPA 1
1 Image
Description: PD-1/PD-L1 interaction inhibitor
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Biological Activity

(D)-PPA 1 is a PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.

Technical Data

M.Wt:
1555.67
Formula:
C70H98N20O21
Sequence:
NYSKPTDRQYHF

(Modifications: Asn-1 = D-Asn, Tyr-2 = D-Tyr, Ser-3 = D-Ser, Lys-4 = D-Lys, Pro-5 = D-Pro, Thr-6 = D-Thr, Asp-7 = D-Asp, Arg-8 = D-Arg, Gln-9 = D-Gln, Tyr-10 = D-Tyr, His-11 = D-His, Phe-12 = D-Phe)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
1620813-53-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy.
    Chang et al.
    Angew Chem.Int.Ed.Engl., 2015;54:11760

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FAQs

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VersaClone cDNA Plasmids

Canine PD-1 (NP_001301026) VersaClone cDNA

RDC2098

Cynomolgus Monkey PD-1 (NP_001271065) VersaClone cDNA

RDC1186

Human PD-1 (NP_005009) VersaClone cDNA

RDC0903

Mouse PD-1 (NP_032824) VersaClone cDNA

RDC0893

Rat PD-1 (NP_001100397) VersaClone cDNA

RDC1908

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