(D)-PPA 1

Catalog # Availability Size / Price Qty
6515/1
Cat.No. 6515 - (D)-PPA 1 | D-Asn-D-Tyr-D-Ser-D-Lys-D-Pro-D-Thr-D-Asp-D-Arg-D-Gln-D-Tyr-D-His-D-Phe | CAS No. 1620813-53-7
1 Image
Description: PD-1/PD-L1 interaction inhibitor
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Biological Activity

PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.

Technical Data

M.Wt:
1555.67
Formula:
C70H98N20O21
Sequence:
NYSKPTDRQYHF

(Modifications: Asn-1 = D-Asn, Tyr-2 = D-Tyr, Ser-3 = D-Ser, Lys-4 = D-Lys, Pro-5 = D-Pro, Thr-6 = D-Thr, Asp-7 = D-Asp, Arg-8 = D-Arg, Gln-9 = D-Gln, Tyr-10 = D-Tyr, His-11 = D-His, Phe-12 = D-Phe)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
1620813-53-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy.
    Chang et al.
    Angew Chem.Int.Ed.Engl., 2015;54:11760

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