Deguelin
Chemical Name: (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
Purity: ≥97%
Biological Activity
Anticancer and antiviral agent; chemopreventive and pro-apoptotic. Inhibits phorbol ester-induced ornithine decarboxylase and NADH:ubiquinone oxidoreductase activities (IC50 values are 11 and 6.9 nM respectively). Inhibits PI 3-kinase and reduces pAkt levels in pre-malignant and malignant human bronchial epithelial cells. Active in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells.
Chun et al.
J.Natl.Cancer Inst., 2003;95:291 -
Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities.
Fang and Casida
Proc.Natl.Acad.Sci.U.S.A., 1998;95:3380 -
Antiviral and antitumor antibiotics. XX. Effects of rotenone, deguelin, and related compounds on animal and plant viruses.
Takatsuki et al.
Appl.Microbiol., 1969;18:660 -
Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid.
Udeani et al.
Cancer Res., 1997;57:3424
Product Datasheets
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Citations for Deguelin
The citations listed below are publications that use Tocris products. Selected citations for Deguelin include:
2 Citations: Showing 1 - 2
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Synergistic Activity of Deguelin and fludar. in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model.
Authors: Rebolleda Et al.
PLoS One 2016;11:e0154159
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BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells.
Authors: Hafeez Et al.
J Neurosci 2016;11:e0145780
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