Deguelin

  ( 2 citations )    
Product Datasheet
Catalog Number:1770
Chemical Name:(7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
Product Details
Citations (2)
Reviews
Biological Activity
Anticancer and antiviral agent; chemopreventive and pro-apoptotic. Inhibits phorbol ester-induced ornithine decarboxylase and NADH:ubiquinone oxidoreductase activities (IC50 values are 11 and 6.9 nM respectively). Inhibits PI 3-kinase and reduces pAkt levels in pre-malignant and malignant human bronchial epithelial cells. Active in vivo.
Technical Data
  • M.Wt:
    394.42
  • Formula:
    C23H22O6
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    522-17-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Deguelin include:

2 Citations: Showing 1 - 2
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  1. Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model.
    Authors: Rebolleda Et al.
    PLoS One  2016;11:e0154159
  2. BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells.
    Authors: Hafeez Et al.
    J Neurosci  2016;11:e0145780

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