Anticancer and antiviral agent; chemopreventive and pro-apoptotic. Inhibits phorbol ester-induced ornithine decarboxylase and NADH:ubiquinone oxidoreductase activities (IC50
values are 11 and 6.9 nM respectively). Inhibits PI 3-kinase and reduces pAkt levels in pre-malignant and malignant human bronchial epithelial cells. Active in vivo
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All Tocris products are intended for laboratory research use only.
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells.
Chun et al.
J.Natl.Cancer Inst., 2003;95:291
Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities.
Fang and Casida
Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid.
Udeani et al.
Cancer Res., 1997;57:3424
Antiviral and antitumor antibiotics. XX. Effects of rotenone, deguelin, and related compounds on animal and plant viruses.
Takatsuki et al.
The citations listed below are publications that use Tocris products. Selected citations for Deguelin include:
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