An endogenous ligand for the ghrelin receptor (GHS-R1a), produced by alternative splicing of the rat ghrelin gene. Potently induces Ca2+
release in cells expressing ghrelin receptors (EC50
= 2.4 nM) and stimulates GH release in vivo
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Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor.
Hosoda et al.