Biological ActivityAn endogenous ligand for the ghrelin receptor (GHS-R1a), produced by alternative splicing of the rat ghrelin gene. Potently induces Ca2+ release in cells expressing ghrelin receptors (EC50 = 2.4 nM) and stimulates GH release in vivo.
(Modifications: Ser-3 = Ser(n-octanoyl))
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Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the GH secretagogue receptor.
Hosoda et al.
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