Catalog Number: 0964
Chemical Name: 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
Biological Activity
Antihypertensive, activates ATP-dependent K+ channels (Kir6). Induces activation of PKCε, an intermediate in the opening of mitoKATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Diazoxide acts more as a PKC-ε activator, and indirectly activates the mitochondiral KATP channel conferring cardioprotection against hypoxic injury.
    Kim et al.
    Br.J.Pharmacol., 2006;149:1059
  3. Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons.
    Yamada and Rothman
    J.Physiol., 1992;458:409
  4. Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic β-cells.
    Trube et al.
    Pflugers Arch., 1986;407:493

The citations listed below are publications that use Tocris products. Selected citations for Diazoxide include:

Showing Results 1 - 1 of 1

  1. Chronic neonatal diazoxide therapy is not associated with adverse effects
    Authors: Cox Et al.
    J Neurosci
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