Chemical Name: 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
Biological ActivityDiazoxide is an antihypertensive, activates ATP-dependent K+ channels (Kir6). Induces activation of PKCε, an intermediate in the opening of mitoKATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Dox acts more as a PKC-ε activator, and indirectly activates the mitochondiral KATP channel conferring cardioprotection against hypoxic injury.
Kim et al.
Dox blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons.
Yamada and Rothman
Opposite effects of tolbut. and Dox on the ATP-dependent K+ channel in mouse pancreatic β-cells.
Trube et al.
Pflugers Arch., 1986;407:493
Citations for Diazoxide
The citations listed below are publications that use Tocris products. Selected citations for Diazoxide include:
4 Citations: Showing 1 - 4
Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel.
Authors: Sun Et al.
Sci Rep 2014;4:4934
Chronic neonatal Dox therapy is not associated with adverse effects
Authors: Cox Et al.
J Neurosci 2014;14:49
Shift in Kiss1 cell activity requires estrogen receptor α.
Authors: Frazão Et al.
J Neurosci 2013;33:2807
Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition.
Authors: Niu Et al.
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