Antihypertensive, activates ATP-dependent K+
6). Induces activation of PKCε
, an intermediate in the opening of mitoKATP
channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
Diazoxide acts more as a PKC-ε activator, and indirectly activates the mitochondiral KATP channel conferring cardioprotection against hypoxic injury.
Kim et al.
Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons.
Yamada and Rothman
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic β-cells.
Trube et al.
Pflugers Arch., 1986;407:493
The citations listed below are publications that use Tocris products. Selected citations for Diazoxide include:
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