Chemical Name: 1,1-Bis(3'-indolyl)-1-(p-methoxyphenyl)methane
Biological ActivityDIM-C-pPhOCH3 is a Nur77 agonist. Induces apoptosis in cancer cell lines in vitro. Enhances long-term potentiation in hippocampal slices and long-term contextual fear memory in an in vivo mouse model.
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Pharmacological activators of the NR4A nuclear receptors enhance LTP in a CREB/CBP-dependent manner.
Bridi et al.
Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.
Chintharlapalli et al.
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