Catalog Number: 1222
Chemical Name: 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride
Biological Activity
A potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.
Technical Data
  • M.Wt:
    339.22
  • Formula:
    C16H14N2O2.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    1123491-15-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase
    Dolle et al.
    J.Med.Chem., 1994;37:2627

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