Dolastatin 10 trifluoroacetate

Name: Dolastatin 10 trifluoroacetate
Brand: Tocris Bioscience
SKU: 3375

Tocris Bioscience | Catalog # 3375

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Product Documents

Tubulin polymerization inhibitor

Discontinued Product

3375 has been discontinued. View all Microtubule Binding Compounds products.

Technical Data
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Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Tubulin polymerization inhibitor

View all Microtubule Binding Compounds »

Product Description

Dolastatin 10 trifluoroacetate is a tubulin polymerization inhibitor. Noncompetitively inhibits binding of radiolabeled vincristine to tubulin (K_i = 1.4 μM) and induces tubulin aggregation in vitro.

Product Specifications for Dolastatin 10 trifluoroacetate

Molecular Weight

899.11

Formula

C₄₂H₆₈N₆O₆S.CF₃CO₂H

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

N,N-Dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazol)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl--valinamide trifluoroacetate

CAS Number

2342568-65-2

PubChem ID

9810929

InChI Key

OFDNQWIFNXBECV-VFSYNPLYSA-N

SMILES

O=C(C[C@@H](OC)[C@@H](N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)[C@@H](C)CC)N1[C@@]([C@H](OC)[C@@H](C)C(N[C@@H](CC3=CC=CC=C3)C2=NC=CS2)=O)([H])CCC1.FC(C(O)=O)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Bai Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. Mol.Pharmacol. 1995 PMID: 7746283
Bai Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J.Biol.Chem. 1990 PMID: 2211617

Product Documents for Dolastatin 10 trifluoroacetate

Certificate of Analysis

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Product Specific Notices for Dolastatin 10 trifluoroacetate

For research use only

Related Research Areas

Microtubules

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