Catalog Number: 0269
Chemical Name: (2S,3S,4R,5'R)-2-Carboxy-4-(5'-carboxy-1'-methyl-1Z,3E-hexadienyl)-3-pyrrolidineacetic acid
Biological Activity
Kainate receptor agonist. More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The primary afferent depolarizing action of kainate in the rat.
    Agrawal and Evans
    Br.J.Pharmacol., 1986;87:345
  2. Domoic acid, the alleged 'mussel toxin', might produce its neurotoxic effect through kainate receptor activation: an electro-physiological study in rat dorsal hippocampus.
    Debonnel et al.
    Can.J.Physiol.Pharmacol., 1989;67:29
  3. The activation of glutamate receptors by kainic acid and domoic acid.
    Hampson and Manalo
    Nat.Toxins, 1998;6:153
  4. Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors.
    Watkins et al.
    Excitatory Amino Acids and Synaptic Plasticity. Ed, 1990;:49
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