Chemical Name: 7-(Diethylamino)-3-(5-methyl-2-benzoxazolyl)-2H-1-benzopyran-2-one
Biological ActivityEMI 48 is an inhibitor of mutant EGFR; it inhibits L858R/T970M/C797S mutants and ex19del/T790M/C797S triple mutants (inhibitory effects at 5 μM) but has no effect on wild-type EGFR. EMI 48 induces EGFR degradation (<5 μM), and inhibits activation of ERK, S6 and AKT.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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