Chemical Name: (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione hydrochloride
Biological ActivityAntibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC50 = 62.7 μM in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Epirubicin: a review of pharmacology, clinical activity, and adverse effects of an adriamycin analogue.
Cersosimo et al.
DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs.
Spadari et al.
Anticancer Res., 1986;6:935
Comparative activity of anthracycline 13-dihydrometabolites against rat glioblastoma cells in culture.
Schott and Robert
Citations for Epirubicin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Epirubicin hydrochloride include:
2 Citations: Showing 1 - 2
A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier.
Authors: Kim and Bynoe
J Clin Invest 2016;126:1717
RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
Authors: Robinson Et al.
PLoS One 2013;8:e78641
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Epirubicin hydrochloride
Average Rating: 5 (Based on 1 Review)
Have you used Epirubicin hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Epirubicin was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.