Catalog Number: 3260
Alternate Names: 4'-Epidoxorubicin
Chemical Name: (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione hydrochloride
Biological Activity
Antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC50 = 62.7 μM in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.
Technical Data
  • M.Wt:
    579.98
  • Formula:
    C27H29NO11.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >97%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    56390-09-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Epirubicin: a review of pharmacology, clinical activity, and adverse effects of an adriamycin analogue.
    Cersosimo et al.
    J.Clin.Oncol., 1986;4:425
  2. DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs.
    Spadari et al.
    Anticancer Res., 1986;6:935
  3. Comparative activity of anthracycline 13-dihydrometabolites against rat glioblastoma cells in culture.
    Schott and Robert
    Biochem.Pharmacol., 1989;38:4069
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Epirubicin hydrochloride include:

1 Citations: Showing 1 - 1

  1. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One 2013;8:e78641

Have you used Epirubicin hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information