Epirubicin hydrochloride

Tocris Bioscience | Catalog # 3260

Inhibits DNA synthesis and function. Inhibits DNA topoisomerase II
Tocris Bioscience
Discontinued Product
3260 has been discontinued. View all DNA, RNA and Protein Synthesis Inhibitors products.

Key Product Details

Description

Inhibits DNA synthesis and function. Inhibits DNA topoisomerase II

Alternative Names

4'-Epidoxorubicin
View all DNA, RNA and Protein Synthesis Inhibitors »

Product Description

Epirubicin hydrochloride is an antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC50 = 62.7 μM in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.

Product Specifications for Epirubicin hydrochloride

Molecular Weight

579.98

Formula

C27H29NO11.HCl

Storage

Desiccate at +4°C

Purity

≥96% (HPLC)

Chemical Name

(8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione hydrochloride

CAS Number

56390-09-1

PubChem ID

32874

InChI Key

MWWSFMDVAYGXBV-FGBJBKNOSA-N

SMILES

O=C(C2=C1C(OC)=CC=C2)C3=C(C(O)=C([C@](OC5CC(N)C(O)C(C)O5)([H])C[C@@]([C@@](CO)=O)(O)C4)C4=C3O)C1=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 29 50
DMSO 58 100

Preparing Stock Solutions for Epirubicin hydrochloride

The following data is based on the product molecular weight 579.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.72 mL 8.62 mL 17.24 mL
5 mM 0.34 mL 1.72 mL 3.45 mL
10 mM 0.17 mL 0.86 mL 1.72 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Epirubicin hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Epirubicin hydrochloride

For research use only

Citations for Epirubicin hydrochloride

Customer Reviews for Epirubicin hydrochloride (2)

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  • Highly stable
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: brain
    Verified Customer | Posted 05/09/2020
    10 mg/kg of epirubicin
    Epirubicin hydrochloride 3260
  • Epirubicin effectively kills melanoma cells in vitro
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 02/14/2019
    Epirubicin was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
    Epirubicin hydrochloride 3260

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