ETP 45835 dihydrochloride

Key Product Details

Product Description

ETP 45835 dihydrochloride is a Mnk2 and Mnk1 inhibitor (IC₅₀ values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein kinases, including those upstream of Mnk1/2.

Product Specifications for ETP 45835 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ETP 45835 dihydrochloride

The following data is based on the product molecular weight 301.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.32 mL	16.60 mL	33.20 mL
5 mM	0.66 mL	3.32 mL	6.64 mL
10 mM	0.33 mL	1.66 mL	3.32 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Oyarzabal Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J.Med.Chem. 2010 PMID: 20722422

Product Documents for ETP 45835 dihydrochloride