Chemical Name: 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)propanimidamide
Biological ActivityFamotidine is a potent and high affinity histamine H2 receptor biased inverse agonist (Kd = 14 nM, IC50 = 33 nM). Reduces basal receptor activity by 75%. Inhibits Gs-mediated pathways but acts as a partial agonist of β-arrestin recruitment (EC50 = 105 nM). Inhibits gastric acid secretion and histamine-induced mast cell activation. Also inhibits HIV replication in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Effect of a new potent H2-blocker, 3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]-thio]-N2-sulfamoylpropionamidine (YM-11170) on gastric secretion induced by histamine and food in conscious dogs.
Takagi et al.
Effects of H2-receptor antagonists upon physiological acid secretory states in animals.
Pendleton et al.
The effect of histamine type 2 receptor antagonists on human immunodeficiency virus (HIV) replication: identification of a new class of antiviral agents.
Bourinbaiar & Fruhstorfer
Life Sci., 1996;59:365
COVID-19: Famotidine, histamine, mast cells, and mechanisms.
Malone et al.
Res.Sq. - Paper not yet peer reviewed, 2020;
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