Fenoprofen calcium

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Fenoprofen calcium | CAS No. 34597-40-5 | Melanocortin Receptor Agonists
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Description: Positive allosteric modulator of MC3 receptors; exhibits biased signaling

Chemical Name: α-Methyl-3-phenoxybenzeneacetic acid hemicalcium salt

Purity: ≥98%

Product Details

Biological Activity

Fenoprofen calcium is a melanocortin 3 (MC3) receptor positive allosteric modulator (PAM; allosteric enhancer) (pEC50 = 8.69); decreases the EC50 of α-MSH at MC3R. Stimulates ERK1/2 activation at MC3-5R, with highest ERK1/2 activation observed at 3 and 10 μM for MC3R, 1 μM for MC4R, and 3 μM for MC5R. Exhibits biased signaling at MC3-5R, selectively activating ERK1/2 cascade but not canonical cAMP signaling. Antiarthritic.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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