Catalog Number: 0658
Chemical Name: N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide
Biological Activity
Binds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC50 = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation.
Technical Data
  • M.Wt:
    436.61
  • Formula:
    C28H37FN2O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    142720-24-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).
    Romeo et al.
    J.Pharmacol.Exp.Ther., 1992;262:971
  2. Synthesis of (2-arylindol-3-yl)acetamides as probes for mitochondrial steroidogenesis - a new mechanism of GABAA receptor modulation.
    Kozikowski et al.
    Angew.Chem.Int.Ed., 1992;31:1060
Citations:

The citations listed below are publications that use Tocris products. Selected citations for FGIN-1-27 include:

1 Citations: Showing 1 - 1

  1. Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway.
    Authors: Sutter Et al.
    Glia 2003;89:564

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