FH 535

Key Product Details

Product Description

FH 535 is an inhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.

Product Specifications for FH 535

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FH 535

The following data is based on the product molecular weight 361.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.69 mL	18.46 mL	36.91 mL
3.75 mM	0.74 mL	3.69 mL	7.38 mL
7.5 mM	0.37 mL	1.85 mL	3.69 mL
37.5 mM	0.07 mL	0.37 mL	0.74 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 18 publications citing the usage of this product.

• Handeli and Simon A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities. Mol.Cancer Ther. 2008 PMID: 18347139

Product Documents for FH 535