Chemical Name: 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
Biological ActivityFH 535 is an inhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities.
Handeli and Simon
Mol.Cancer Ther., 2008;7:521
Citations for FH 535
The citations listed below are publications that use Tocris products. Selected citations for FH 535 include:
4 Citations: Showing 1 - 4
The antimicrobial peptide S100A8/A9 produced by airway epithelium functions as a potent and direct regulator of macrophage phenotype and function.
Authors: Stefan Et al.
Eur Respir J 2022;59
Insulin-like growth factor binding protein 4 inhibits proliferation of bone marrow mesenchymal stem cells and enhances growth of neurospheres derived from the stem cells.
Authors: Qunyuan Et al.
Cell Biochem Funct 2018;36:331-341
Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair.
Authors: Lan Et al.
Cell Res 2017;27:1002-1019
Metabolic origins of spatial organization in the tumor microenvironment.
Authors: Craig B Et al.
Proc Natl Acad Sci U S A 2017;114:2934-2939
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