Chemical Name: 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
Biological ActivityInhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities.
Handeli and Simon
Mol.Cancer Ther., 2008;7:521
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VersaClone cDNA Plasmids
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