Inhibitor of Wnt/β
-catenin signaling and dual antagonist of PPARγ
activity. Suppresses β
-catenin/Tcf-mediated transcription; inhibits β
-catenin and GRIP1 recruitment to PPARγ
. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.
Soluble to 75 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities.
Handeli and Simon
Mol.Cancer Ther., 2008;7:521