FH 535

Catalog # Availability Size / Price Qty
4344/10
4344/50
beta-Catenin Inhibitors Small Molecule
1 Image
Description: Inhibitor of Wnt/β-catenin signaling

Chemical Name: 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide

Purity: ≥99%

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Biological Activity

Inhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.

Technical Data

M.Wt:
361.2
Formula:
C13H10Cl2N2O4S
Solubility:
Soluble to 75 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
108409-83-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities.
    Handeli and Simon
    Mol.Cancer Ther., 2008;7:521

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