Home / beta-Catenin Inhibitors / FH 535

FH 535

Catalog #: 4344
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4344/10
4344/50
FH 535 | CAS No. 108409-83-2 | beta-Catenin Inhibitors
1 Image
Description: Inhibitor of Wnt/β-catenin signaling

Chemical Name: 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide

Purity: ≥99%

Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

FH 535 is an inhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.

Technical Data

M.Wt:
361.2
Formula:
C13H10Cl2N2O4S
Solubility:
Soluble to 75 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
108409-83-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities.
    Handeli and Simon
    Mol.Cancer Ther., 2008;7:521

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for FH 535

The citations listed below are publications that use Tocris products. Selected citations for FH 535 include:

4 Citations: Showing 1 - 4

  1. The antimicrobial peptide S100A8/A9 produced by airway epithelium functions as a potent and direct regulator of macrophage phenotype and function.
    Authors: Stefan Et al.
    Eur Respir J  2022;59
  2. Insulin-like growth factor binding protein 4 inhibits proliferation of bone marrow mesenchymal stem cells and enhances growth of neurospheres derived from the stem cells.
    Authors: Qunyuan Et al.
    Cell Biochem Funct  2018;36:331-341
  3. Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair.
    Authors: Lan Et al.
    Cell Res  2017;27:1002-1019
  4. Metabolic origins of spatial organization in the tumor microenvironment.
    Authors: Craig B Et al.
    Proc Natl Acad Sci U S A  2017;114:2934-2939

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

VersaClone cDNA Plasmids

Human beta-Catenin (NP_001895) VersaClone cDNA

RDC2388
1 Image

Reviews for FH 535

There are currently no reviews for this product. Be the first to review FH 535 and earn rewards!

Have you used FH 535?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.