Chemical Name: Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
Biological ActivityInhibitor of Notch signaling (EC50 = 2.3 μM). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecules intercept Notch signaling and the early secretory pathway.
Krämer et al.
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VersaClone cDNA Plasmids
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