FLI 06

   
Product Datasheet
Catalog Number:5172
Chemical Name:Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
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Biological Activity
Inhibitor of Notch signaling (EC50 = 2.3 μM). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets.
Technical Data
  • M.Wt:
    438.52
  • Formula:
    C25H30N2O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    313967-18-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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VersaClone cDNA Plasmids
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Human Notch-4 (NP_004548) VersaClone cDNA

RDC1794
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Human Notch-1 (NP_060087) VersaClone cDNA

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