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FLI 06

Catalog #: 5172 Datasheet / COA / SDS

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5172 has been discontinued.
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FLI 06 | CAS No. 313967-18-9 | Translocation, Exo/Endocytosis Products
1 Image
Description: Inhibitor of Notch signaling; disrupts Notch trafficking and processing

Chemical Name: Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate

Purity: ≥99%

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Biological Activity

FLI 06 is an inhibitor of Notch signaling (EC50 = 2.3 μM). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets.

Technical Data

M.Wt:
438.52
Formula:
C25H30N2O5
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
313967-18-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small molecules intercept Notch signaling and the early secretory pathway.
    Krämer et al.
    Nat.Chem.Biol., 2013;9:731

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