Inhibitor of Notch signaling (EC50
= 2.3 μ
M). Disrupts Notch trafficking and processing. Reduces amyloid β
secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Small molecules intercept Notch signaling and the early secretory pathway.
Krämer et al.