Chemical Name: (5Z)-4-Bromo-5-(bromomethylene)-2(5H)-furanone
Biological ActivitySynthetic furanone bacterial quorum sensing inhibitor. Inhibits virulence factor expression in Pseudomonas aeruginosa and increases bacterial susceptibility to antibiotics in vitro. Also inhibits bacterial quorum sensing in vivo and promotes bacterial clearance in a mouse pulmonary infection model.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors.
Hentzer et al.
EMBO J., 2003;22:3803
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