Chemical Name: 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Biological ActivityGalangin is a TRPC5 inhibitor. Inhibits Ca2+ entry into TRPC5 expressing cells. Inhibits LPS-induced expression of TNFα, IL-6, IL-1β, COX2 and iNOS, in vitro. Attenuates microglial activation, loss of dopaminergic neurons and motor dysfunction in a LPS-induced rat model of Parkinson's disease. Also inhibits proliferation in breast cancer cell lines. Induces autophagy. Also displays antiviral activity against HSV-1, coxsackie B virus type 1, adenovirus type 31 and reovirus.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Natural and synthetic flavonoid modulation of TRPC5 channels.
Naylor et al.
Galangin reduces the loss of DArgic neurons in an LPS-evoked model of Parkinson's disease in rats.
Chen et al.
Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices.
So et al.
Galangin induces autophagy through upregulation of p53 in HepG2 cells.
Wen et al.
Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens.
Meyer et al.
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