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Galangin | CAS No. 548-83-4 | TRPC Channel Blockers
1 Image
Description: TRPC5 inhibitor; also induces autophagy

Chemical Name: 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details

Biological Activity

Galangin is a TRPC5 inhibitor. Inhibits Ca2+ entry into TRPC5 expressing cells. Inhibits LPS-induced expression of TNFα, IL-6, IL-1β, COX2 and iNOS, in vitro. Attenuates microglial activation, loss of dopaminergic neurons and motor dysfunction in a LPS-induced rat model of Parkinson's disease. Also inhibits proliferation in breast cancer cell lines. Induces autophagy. Also displays antiviral activity against HSV-1, coxsackie B virus type 1, adenovirus type 31 and reovirus.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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