Chemical Name: 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Biological ActivityTRPC5 inhibitor. Inhibits Ca2+ entry into TRPC5 expressing cells. Inhibits LPS-induced expression of TNFα, IL-6, IL-1β, COX2 and iNOS, in vitro. Attenuates microglial activation, loss of dopaminergic neurons and motor dysfunction in a LPS-induced rat model of Parkinson's disease. Also inhibits proliferation in breast cancer cell lines. Induces autophagy.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Natural and synthetic flavonoid modulation of TRPC5 channels.
Naylor et al.
Galangin reduces the loss of dopaminergic neurons in an LPS-evoked model of Parkinson's disease in rats.
Chen et al.
Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices.
So et al.
Galangin induces autophagy through upregulation of p53 in HepG2 cells.
Wen et al.
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