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Goserelin acetate

3592 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3592/10
Goserelin acetate
1 Image
Description: GnRH receptor agonist
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Biological Activity

Synthetic gonadotropin-releasing hormone (GnRH) analog that behaves as an agonist at the GnRH receptors. Stimulates gonadotropin and sex hormone release in the short term, and causes suppression with continued administration. Displays antiproliferative activity in breast, prostate and endometrial cancers.

Technical Data

M.Wt:
1269.42
Formula:
C59H84N18O14
Sequence:
XHWSYSLRP

(Modifications: X = Pyr, Ser-4 = t-Bu-Ser, Pro-9 = terminal NH-NH-CO-NH2)

Solubility:
Soluble in water
Storage:
Desiccate at -20°C
CAS No:
145781-92-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop.
    Dondi et al.
    Cancer Res., 1994;54:4091
  2. The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor.
    Chatzaki et al.
    Cancer Res., 1996;56:2059
  3. Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use in sex-hormone-related conditions.
    Chrisp and Goa
    Drugs, 1991;2:254

Product Datasheets

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Reconstitution Calculator

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⚠ WARNING: This product can expose you to chemicals including Goserelin acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

FAQs

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VersaClone cDNA Plasmids

Rat GnRHR (NP_112300) VersaClone cDNA

RDC0611

Mouse GnRHR (NP_034453) VersaClone cDNA

RDC0415

Human GnRHR (NP_000397) VersaClone cDNA

RDC0324

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