Goserelin acetate

Name: Goserelin acetate
Brand: Tocris Bioscience
SKU: 3592

Tocris Bioscience | Catalog # 3592

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Product Documents

GnRH receptor agonist

Discontinued Product

3592 has been discontinued. View all GnRH Agonist products.

Technical Data
Reviews

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

GnRH receptor agonist

View all GnRH Agonist »

Product Description

Goserelin acetate is a synthetic gonadotropin-releasing hormone (GnRH) analog that behaves as an agonist at the GnRH receptors. Stimulates gonadotropin and sex hormone release in the short term, and causes suppression with continued administration. Displays antiproliferative activity in breast, prostate and endometrial cancers.

Product Specifications for Goserelin acetate

Molecular Weight

1269.42

Formula

C₅₉H₈₄N₁₈O₁₄

Storage

Desiccate at -20°C

CAS Number

145781-92-6

PubChem ID

90488862

InChI Key

BLCLNMBMMGCOAS-JFBCNRKLSA-N

SMILES

[H]N([C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NNC(N)=O)C(=O)C1CCC(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Chatzaki The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor. Cancer Res. 1996 PMID: 8616851
Chrisp and Goa Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use in sex-hormone-related conditions. Drugs
Dondi Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop. Cancer Res. 1994 PMID: 8033142

Product Documents for Goserelin acetate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Goserelin acetate

For research use only

⚠ WARNING: This product can expose you to chemicals including Goserelin acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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