Chemical Name: 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide
Biological ActivityGR 46611 is a 5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Evolution of a novel series of [(N,N-Dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists.
Clitherow et al.
Stimulation of central 5-HT1D receptors causes hypothermia in the guinea pig.
Skingle et al.
Citation for GR 46611
The citations listed below are publications that use Tocris products. Selected citations for GR 46611 include:
1 Citation: Showing 1 - 1
Effect of 5-hydroxytryptamine1 serotonin receptor agonists on noxiously stimulated micturition in cats with chronic spinal cord injury.
Authors: Gu Et al.
J Urol 2007;177:2381
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