Catalog Number: 0864
Chemical Name: 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide
Biological Activity
5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands.
Technical Data
  • M.Wt:
    377.49
  • Formula:
    C23H27N3O2
  • Solubility:
    Soluble to 50 mM in DMSO and to 10 mM in ethanol
  • Storage:
    Store at RT
  • CAS No:
    185259-85-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. Evolution of a novel series of [(N,N-Dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists.
    Clitherow et al.
    J.Med.Chem., 1994;37:2253
  2. Stimulation of central 5-HT1D receptors causes hypothermia in the guinea pig.
    Skingle et al.
    J.Psychopharmacol., 1994;8:14

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