GSK 591 dihydrochloride

Tocris Bioscience | Catalog # 5777

Potent and selective PRMT5 inhibitor
Tocris Bioscience
Discontinued Product
5777 has been discontinued. View all Protein Arginine Methyltransferase Inhibitors products.

Key Product Details

Description

Potent and selective PRMT5 inhibitor

Alternative Names

EPZ015866,GSK 3203591
View all Protein Arginine Methyltransferase Inhibitors »

Product Description

GSK 591 dihydrochloride is a potent and selective PRMT5 inhibitor (IC50 = 4 nM). Selective for PRMT5 over a panel of other PRMTs and lysine methyltransferases. Inhibits proliferation of mantle cell lymphoma (MCL) in vitro.

To request the negative control for GSK 591, please fill out the SGC 2096 request form on the SGC website.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK591 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK591 is reviewed on the Chemical Probes website.

Product Specifications for GSK 591 dihydrochloride

Molecular Weight

453.41

Formula

C22H28N4O2.2HCl

Storage

Desiccate at RT

Purity

≥97% (HPLC)

Chemical Name

2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydropropyl]-4-pyridinecarboxamide dihydrochloride

CAS Number

2320953-89-5

PubChem ID

124201849

InChI Key

CDKUMVXFXBTOBE-FJSYBICCSA-N

SMILES

O[C@@H](CNC(C1=CC=NC(NC2CCC2)=C1)=O)CN3CC4=CC=CC=C4CC3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 45.34 100
DMSO 45.34 100

Preparing Stock Solutions for GSK 591 dihydrochloride

The following data is based on the product molecular weight 453.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.03 mL 22.06 mL
5 mM 0.44 mL 2.21 mL 4.41 mL
10 mM 0.22 mL 1.10 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for GSK 591 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GSK 591 dihydrochloride

For research use only

Related Research Areas

Epigenetics

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