Histone lysine demethylase (KDM) inhibitor; blocks demethylation of histone H3K27. Attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50
= 9 μ
M for the inhibition of TNFα
release). Cell permeable. Ethyl ester derivative of GSK J1
(Cat. No. 4593).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details of GSK J4, a cell permeable derivative of GSK J1, please visit the GSK J1 probe summary
on the SGC website.
Other Product-Specific Information:
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
Kruidenier et al.
Inhibition of demethylases by GSK-J1/J4.
Heinemann et al.
The citations listed below are publications that use Tocris products. Selected citations for GSK J4 include:
Showing Results 1 - 6 of 6