GSK J1

Key Product Details

Product Description

GSK J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) (IC₅₀ values are 28 and 53 nM respectively). Also inhibits KDM5B, KDM5C and KDM5A (IC₅₀ values are 170, 550 and 6,800 nM respectively). Exhibits no activity against a panel of other histone demethylases (IC₅₀ >20 μM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30 μM.

Ethyl ester derivative and Negative Control also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK J1 probe summary on the SGC website.

Product Specifications for GSK J1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GSK J1

The following data is based on the product molecular weight 389.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.84 mL	25.68 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.28 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Heinemann Inhibition of demethylases by GSK-J1/J4. Nature 2014 PMID: 25279926
• Kruidenier A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 2012 PMID: 22842901

Product Documents for GSK J1