Potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) (IC50
values are 28 and 53 nM respectively). Also inhibits KDM5B, KDM5C and KDM5A (IC50
values are 170, 550 and 6,800 nM respectively). Exhibits no activity against a panel of other histone demethylases (IC50
M), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30 μ
M. Ethyl ester derivative
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK J1 probe summary
on the SGC website.
Other Product-Specific Information:
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
Kruidenier et al.
Inhibition of demethylases by GSK-J1/J4.
Heinemann et al.
The citations listed below are publications that use Tocris products. Selected citations for GSK J1 include:
Showing Results 1 - 2 of 2