Catalog Number: 3385
Chemical Name: 2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamide trihydrochloride
Biological Activity
P2X7 allosteric modulator. Exhibits species-specific activity; acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X7.
Technical Data
  • M.Wt:
    483.81
  • Formula:
    C20H24F2N4O.3HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    309712-55-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Negative and positive allosteric modulators of the P2X7 receptor.
    Michel et al.
    Br.J.Pharmacol., 2008;153:737
  2. Identification of regions of the P2X7 receptor that contribute to human and rat species differences in antagonist effects.
    Michel et al.
    Br.J.Pharmacol., 2008;155:738
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