GW 791343 hydrochloride
Chemical Name: 2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamide trihydrochloride
Purity: ≥99%
Biological Activity
GW 791343 hydrochloride is a P2X7 allosteric modulator. Exhibits species-specific activity; acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X7.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Negative and positive allosteric modulators of the P2X7 receptor.
Michel et al.
Br.J.Pharmacol., 2008;153:737 -
Identification of regions of the P2X7 receptor that contribute to human and rat species differences in antagonist effects.
Michel et al.
Br.J.Pharmacol., 2008;155:738
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