H2L5186303

Tocris Bioscience | Catalog # 4878

Potent and selective LPA2 receptor antagonist
Tocris Bioscience
Discontinued Product
4878 has been discontinued. View all Lysophosphatidic Acid (LPA) Receptor Antagonists products.

Key Product Details

Description

Potent and selective LPA2 receptor antagonist
View all Lysophosphatidic Acid (LPA) Receptor Antagonists »

Product Description

H2L5186303 is a potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 values are 8.9, 1230 and 27354 nM for LPA2, LPA3 and LPA1 receptors respectively, in a LPA-elicited calcium mobilization assay).

Product Specifications for H2L5186303

Molecular Weight

488.45

Formula

C26H20N2O8

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid

CAS Number

139262-76-3

PubChem ID

90488981

InChI Key

HZFPOTBCYPWQSH-DZDAAMPGSA-N

SMILES

O=C(/C=C\C(O)=O)NC(C=C3)=CC=C3OC1=CC(OC2=CC=C(NC(/C=C\C(O)=O)=O)C=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.84 100

Preparing Stock Solutions for H2L5186303

The following data is based on the product molecular weight 488.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.24 mL 20.47 mL
5 mM 0.41 mL 2.05 mL 4.09 mL
10 mM 0.20 mL 1.02 mL 2.05 mL
50 mM 0.04 mL 0.20 mL 0.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Product Documents for H2L5186303

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for H2L5186303

For research use only

Customer Reviews for H2L5186303 (1)

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  • Works as a negative control for LPA effects in culture.
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: primary mammary epithelium
    Verified Customer | Posted 11/18/2018
    Mouse Mammary epithelial cells were used in a standard mammosphere generating assay in a serum-free (B27 supplement), non-adherent condition. LPA or LPA antagonist (H2L5186303) were added to media and the number of spheres were counted after 6 days of culture. Results showed that 10 uM of the antagonist ameliorated most of the LPA-induced suppression, but did not fully neutralize LPA effects. Of two tested LPA inhibitors (products #4878, #5913), this was less effective by a small margin.
    H2L5186303 4878

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