Catalog Number: 4878
Chemical Name: (Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid
Biological Activity
Potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 values are 8.9, 1230 and 27354 nM for LPA2, LPA3 and LPA1 receptors respectively, in a LPA-elicited calcium mobilization assay).
Technical Data
  • M.Wt:
    488.45
  • Formula:
    C26H20N2O8
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    139262-76-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of non-lipid LPA3 antagonists by virtual screening.
    Fells et al.
    Bioorg.Med.Chem., 2008;16:6207
  2. Structure-based drug design identifies novel LPA3 antagonists.
    Fells et al.
    Bioorg.Med.Chem., 2009;17:7457
Citations:

The citations listed below are publications that use Tocris products. Selected citations for H2L5186303 include:

1 Citations: Showing 1 - 1

  1. Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.
    Authors: Wu Et al.
    PLoS One 2015;117:e41

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