Chemical Name: (Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid
Biological ActivityPotent and selective lysophosphatidic acid 2 (LPA 2 ) receptor antagonist (IC 50 values are 8.9, 1230 and 27354 nM for LPA 2 LPA 3 and LPA 1 receptors respectively, in a LPA-elicited calcium mobilization assay).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of non-lipid LPA3 antagonists by virtual screening.
Fells et al.
Structure-based drug design identifies novel LPA3 antagonists.
Fells et al.
Citation for H2L5186303
The citations listed below are publications that use Tocris products. Selected citations for H2L5186303 include:
1 Citation: Showing 1 - 1
Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.
Authors: Wu Et al.
PLoS One 2015;117:e41
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for H2L5186303
Average Rating: 4 (Based on 1 Review)
Have you used H2L5186303?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Mouse Mammary epithelial cells were used in a standard mammosphere generating assay in a serum-free (B27 supplement), non-adherent condition. LPA or LPA antagonist (H2L5186303) were added to media and the number of spheres were counted after 6 days of culture. Results showed that 10 uM of the antagonist ameliorated most of the LPA-induced suppression, but did not fully neutralize LPA effects. Of two tested LPA inhibitors (products #4878, #5913), this was less effective by a small margin.