H2L5186303

Catalog # Availability Size / Price Qty
4878/10
4878/50
Cat.No. 4878 - H2L5186303 | C26H20N2O8 | CAS No. 139262-76-3
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Description: Potent and selective LPA2 receptor antagonist

Chemical Name: (Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews

Biological Activity

Potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 values are 8.9, 1230 and 27354 nM for LPA2, LPA3 and LPA1 receptors respectively, in a LPA-elicited calcium mobilization assay).

Technical Data

M.Wt:
488.45
Formula:
C26H20N2O8
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
139262-76-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Identification of non-lipid LPA3 antagonists by virtual screening.
    Fells et al.
    Bioorg.Med.Chem., 2008;16:6207
  2. Structure-based drug design identifies novel LPA3 antagonists.
    Fells et al.
    Bioorg.Med.Chem., 2009;17:7457

Product Datasheets

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Citation for H2L5186303

The citations listed below are publications that use Tocris products. Selected citations for H2L5186303 include:

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