Hemokinin 1 (human)

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2576/1
Hemokinin 1 (human)
1 Image
Description: Endogenous and selective NK1 agonist
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Biological Activity

Endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.

Technical Data

M.Wt:
1185.4
Formula:
C54H84N14O14S
Sequence:
TGKASQFFGLM

(Modifications: Met- 11= C-terminal amide)

Solubility:
Soluble to 0.70 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
491851-53-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological profile of the novel mammalian tachykinin hemokinin 1.
    Bellucci et al.
    Br.J.Pharmacol., 2002;135:266
  2. Identification, localization and receptor characterization of novel mammalian substance P-like peptides.
    Kurtz et al.
    Gene, 2002;296:205
  3. Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis.
    Zhang et al.
    Nature Immunol., 2000;1:392

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