Hemokinin 1 (human)

Name: Hemokinin 1 (human)
Brand: Tocris Bioscience
SKU: 2576

Tocris Bioscience | Catalog # 2576

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Product Documents

Endogenous and selective NK1 agonist

Discontinued Product

2576 has been discontinued. View all NK1 Receptor Agonists products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Endogenous and selective NK1 agonist

View all NK1 Receptor Agonists »

Product Description

Hemokinin 1 (human) is an endogenous substance P homolog that is a selective agonist at the tachykinin NK₁ receptor (IC₅₀ values are 1.8, 370 and 480 nM for NK₁, NK₃ and NK₂ receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.

Product Specifications for Hemokinin 1 (human)

Molecular Weight

1185.40

Formula

C₅₄H₈₄N₁₄O₁₄S

Storage

Desiccate at -20°C

CAS Number

491851-53-7

PubChem ID

71311766

InChI Key

NYBLUYYRUFKGTB-XJCFQSCISA-N

SMILES

[H]N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 0.7mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Kurtz Identification, localization and receptor characterization of novel mammalian substance P-like peptides. Gene 2002 PMID: 12383518
Zhang Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nature Immunol.
Bellucci Pharmacological profile of the novel mammalian tachykinin hemokinin 1. Br.J.Pharmacol. 2002 PMID: 11786503

Product Documents for Hemokinin 1 (human)

Certificate of Analysis

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Product Specific Notices for Hemokinin 1 (human)

For research use only

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