Catalog Number: 4111
Chemical Name: N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide
Biological Activity
Nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro.
    Karavaev et al.
    Neurosci.Behav.Physiol., 2008;38:297
  2. Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin.
    Dasgupta et al.
    Proc.Natl.Acad.Sci., 2010;103:6332
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