Hexamethonium bromide

Catalog # Availability Size / Price Qty
4111/50
Additional Nicotinic Receptor Antagonists Small Molecule
1 Image
Description: Non-competitive nAChR antagonist

Chemical Name: N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide

Product Details
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Reviews (1)

Biological Activity

Nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.

Technical Data

M.Wt:
362.19
Formula:
C12H30Br2N2
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Storage:
Desiccate at RT
CAS No:
55-97-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro.
    Karavaev et al.
    Neurosci.Behav.Physiol., 2008;38:297
  2. Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin.
    Dasgupta et al.
    Proc.Natl.Acad.Sci., 2010;103:6332

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Nicotinic blocker for decreasing stimulated dopamine release
By Anonymous on 05/15/2018
Species: Mouse

This is a fantastic drug for examining nicotinic receptor effects. It is easy to work with for slice recordings and washes out nicely. We typically use 50-200uM concentrations.


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