Catalog Number: 4111
Chemical Name: N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide
Biological Activity
Nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.
Technical Data
  • M.Wt:
    362.19
  • Formula:
    C12H30Br2N2
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
    55-97-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro.
    Karavaev et al.
    Neurosci.Behav.Physiol., 2008;38:297
  2. Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin.
    Dasgupta et al.
    Proc.Natl.Acad.Sci., 2010;103:6332

Have you used Hexamethonium bromide?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information