Nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro
. Inhibits nicotine-mediated induction of XIAP and survivin.
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The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro.
Karavaev et al.
Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin.
Dasgupta et al.