Chemical Name: N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide
Biological ActivityHexamethonium bromide is a nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro.
Karavaev et al.
Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin.
Dasgupta et al.
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This is a fantastic drug for examining nicotinic receptor effects. It is easy to work with for slice recordings and washes out nicely. We typically use 50-200uM concentrations.