Hexamethonium bromide

Tocris Bioscience | Catalog # 4111

Non-competitive nAChR antagonist
Tocris Bioscience
Discontinued Product
4111 has been discontinued. View all Additional Nicotinic Receptor Antagonists products.

Key Product Details

Description

Non-competitive nAChR antagonist
View all Additional Nicotinic Receptor Antagonists »

Product Description

Hexamethonium bromide is a nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.

Product Specifications for Hexamethonium bromide

Molecular Weight

362.19

Formula

C12H30Br2N2

Storage

Desiccate at RT

Chemical Name

N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide

CAS Number

55-97-0

PubChem ID

5938

InChI Key

FAPSXSAPXXJTOU-UHFFFAOYSA-L

SMILES

C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 36.22 100
DMSO 18.11 50

Preparing Stock Solutions for Hexamethonium bromide

The following data is based on the product molecular weight 362.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.80 mL 27.61 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for Hexamethonium bromide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Hexamethonium bromide

For research use only

Citations for Hexamethonium bromide

Customer Reviews for Hexamethonium bromide (1)

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  • Nicotinic blocker for decreasing stimulated dopamine release
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 05/15/2018
    This is a fantastic drug for examining nicotinic receptor effects. It is easy to work with for slice recordings and washes out nicely. We typically use 50-200uM concentrations.
    Hexamethonium bromide 4111

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