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Hexamethonium bromide

Catalog #: 4111 Datasheet / COA / SDS

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Hexamethonium bromide | CAS No. 55-97-0 | Additional Nicotinic Receptor Antagonists
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Description: Non-competitive nAChR antagonist

Chemical Name: N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide

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Biological Activity

Hexamethonium bromide is a nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.

Technical Data

M.Wt:
362.19
Formula:
C12H30Br2N2
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Storage:
Desiccate at RT
CAS No:
55-97-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro.
    Karavaev et al.
    Neurosci.Behav.Physiol., 2008;38:297
  2. Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin.
    Dasgupta et al.
    Proc.Natl.Acad.Sci., 2010;103:6332

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