Home / Additional Nicotinic Receptor Antagonists / Hexamethonium bromide

Hexamethonium bromide

Catalog #: 4111
5 Citations Datasheet / COA / SDS

Discontinued Product

4111 has been discontinued.
View all Additional Nicotinic Receptor Antagonists products.
Hexamethonium bromide | CAS No. 55-97-0 | Additional Nicotinic Receptor Antagonists
1 Image
Description: Non-competitive nAChR antagonist

Chemical Name: N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Hexamethonium bromide is a nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.

Technical Data

M.Wt:
362.19
Formula:
C12H30Br2N2
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Storage:
Desiccate at RT
CAS No:
55-97-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro.
    Karavaev et al.
    Neurosci.Behav.Physiol., 2008;38:297
  2. Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin.
    Dasgupta et al.
    Proc.Natl.Acad.Sci., 2010;103:6332

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Hexamethonium bromide

The citations listed below are publications that use Tocris products. Selected citations for Hexamethonium bromide include:

5 Citations: Showing 1 - 5

  1. Patch clamp recording from bipolar cells in the wholemount mouse retina.
    Authors: Tomomi Et al.
    STAR Protoc  2022;3:101482
  2. Cholinergic feedback to bipolar cells contributes to motion detection in the mouse retina.
    Authors: Robert G Et al.
    Cell Rep  2021;37:110106
  3. Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels.
    Authors: Gertjan Et al.
    PLoS Biol  2021;19:e3001070
  4. GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.
    Authors: Bernhard Et al.
    Elife  2021;10
  5. Identifying roles for peptidergic signaling in mice.
    Authors: Xin-Ming Et al.
    Proc Natl Acad Sci U S A  2019;116:20169-20179

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Hexamethonium bromide

There are currently no reviews for this product. Be the first to review Hexamethonium bromide and earn rewards!

Have you used Hexamethonium bromide?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.