HPI 1

Catalog # Availability Size / Price Qty
3839/10
3839/50
Cat.No. 3839 - HPI 1 | C27H29NO6 | CAS No. 599150-20-6
1 Image
Description: Inhibits Hedgehog signaling

Chemical Name: 1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester

Purity: ≥95%

Product Details
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Biological Activity

Hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC50 = 2.5 μM); inhibits the proliferation of cerebellar granule neuron precursors expressing SmoM2. Does not inhibit Wnt signaling.

Technical Data

M.Wt:
463.52
Formula:
C27H29NO6
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
599150-20-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
    Hyman et al.
    Proc.Natl.Acad.Sci.USA, 2009;106:14132

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