Hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50
values are 1.5, 1.5, 4 and 6 μ
M for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC50
= 2.5 μ
M); inhibits the proliferation of cerebellar granule neuron precursors expressing SmoM2. Does not inhibit Wnt signaling.
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All Tocris products are intended for laboratory research use only.
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
Hyman et al.