Human CD45RA Alexa Fluor® 532-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CD45RA

CD45RA is a single chain type I glycoprotein that is encoded by the human PTPRC gene.  In humans, CD45RA is one of six isoforms of the CD45 complex. These different isoforms are the result of alternative splicing and some of the other isoforms include CD45RO, CD45RB, and CD45RC. CD45RO, CD45RB, CD45RC, and CD45RA are primarily expressed on T cells. CD45RA contains exons 3, 4, and 7 but lacks both exons 5 and 6; CD45RC contains exons 3, 6, and 7. CD45RO contains exons 3 and 7 whereas CD45RB contains exons 3, 5, and 7. Both CD45RA and CD45RB are highly expressed on naïve T cells whereas CD45RO is expressed on activated and memory T cells in addition to some B cell subsets and activated monocytes. Both CD45RA and CD45RO are routinely used to characterize different subsets of Memory T cells.

Product Datasheets

Related Research Areas

• Airway Inflammation and Remodeling
• Basophils
• Eosinophils
• Epigenetics
• Granulocyte Markers
• Mesenchymal Stem Cell Markers
• Monocyte Markers
• Negative Regulators of the Jak/STAT Pathway
• Neutrophils
• Osteoblast and Osteoclast Markers
• Phosphatases and Regulators
• Phosphatases in the Akt Pathway
• Regulatory T Cells (Tregs)
• Search Kinases and Phosphatases
• T Cell Antigen Recognition