Human gamma-Glutamylcyclotransferase/CRF21 Alexa Fluor® 405-conjugated Antibody

Catalog #: AF5086V Datasheet / COA / SDS

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AF5086V-100UG

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All gamma-Glutamylcyclotransferase/CRF21 Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human gamma-Glutamylcyclotransferase/CRF21 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human gamma ‑Glutamylcyclotransferase/CRF21 in Western blots.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human Î³â€‘Glutamylcyclotransferase/CRF21
Met1-Leu188
Accession # O75223

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: gamma-Glutamylcyclotransferase/CRF21

Gamma-glutamylcyclotransferase (GGCT; also Cytochrome c-releasing factor 21, CRF21, C7orf24 or LOC79017) is a 21 kDa AIG2-like family member. It is a cytosolic protein that induces the release of Cytochrome c from mitochondria, possibly initiating apoptosis. Human CRF21 is 188 amino acids (aa) in length and is a complex of beta -sheets and alpha -helices that create two terminal domains. It has been proposed that CRF21 forms homodimers. There are at least two possible splice variants of human CRF21, one showing a 70 aa substitution, while the second variant shows an 18 aa substitution for aa 97‑188. Full-length human CRF21 is 82% aa identical to mouse CRF21.

Long Name

Cytochrome c Releasing Factor 21

Entrez Gene IDs

79017 (Human); 110175 (Mouse); 685702 (Rat)

Alternate Names

C7orf24; CRF21; gammaGlutamylcyclotransferase; gamma-Glutamylcyclotransferase; GCTG; GGC; GGCT; LOC79017; MGC3077