Human Histone Deacetylase 4 (NP_006028.2) VersaClone cDNA

R&D Systems | Catalog # RDC3086

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Key Product Details

Species

Human

Accession Number

NP_006028.2

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Histone Deacetylase 4/HDAC4

Chromatin is a highly specialized structure composed of tightly compacted chromosomal DNA. Gene expression within the nucleus is controlled, in part, by a host of protein complexes which continuously pack and unpack the chromosomal DNA. One of the known mechanisms of this packing and unpacking process involves the acetylation and deacetylation of the histone proteins comprising the nucleosomal core. Acetylated histone proteins confer accessibility of the DNA template to the transcriptional machinery for expression. Histone deacetylases (HDACs) are chromatin remodeling factors that deacetylate histone proteins and thus, may act as transcriptional repressors. HDACs are classified by their sequence homology to the yeast HDACs and there are currently 2 classes. Class I proteins are related to Rpd3 and members of class II resemble Hda1p.

Long Name

Histone Deacetylase 4

Alternate Names

HDAC4

Entrez Gene IDs

9759 (Human); 208727 (Mouse); 363287 (Rat)

Gene Symbol

HDAC4

UniProt

NP_006028.2

Additional Histone Deacetylase 4/HDAC4 Products

Product Documents for Human Histone Deacetylase 4 (NP_006028.2) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Human Histone Deacetylase 4 (NP_006028.2) VersaClone cDNA

For research use only

Related Research Areas

Adult Neurogenesis
Epigenetics

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