Human Importin alpha 3/KPNA4 Alexa Fluor® 594-conjugated Antibody

Catalog #: FAB8204T Datasheet / COA / SDS

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FAB8204T-100UG

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Human Importin alpha 3/KPNA4 Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Importin alpha 3/KPNA4 in ELISA and Western blot. In direct ELISA, no cross-reactivity to human KPNA3 was detected.

Source

Monoclonal Mouse IgG2b Clone # 843124

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Importin Î±3/KPNA4
Met1-Asn104
Accession # O00629

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Importin alpha 3/KPNA4

KPNA4 (Karyopherin subunit alpha 4), also called Importin subunit a4 or Importin aQ1 (previously called Qip1 or Importin a3) is an approximately 58-60 kDa member of the Importin alpha family of proteins. It is ubiquitously expressed, and found in both nucleus and cytoplasm. KPNA4 functions as a cargo carrier that transports various complexes from cytoplasm into nucleus. Human KPNA4 is a 521 amino acid (aa) protein that contains an N-terminal IBB/Importin b domain (aa 2-58), ten Armadillo repeats that bind “cargo” (aa 66-485) and two intervening NLS binding sites. Human KPNA4 aa 1-104 share 99% aa identity with mouse and rat KPNA4, which in turn share 100% identity with each other.

Long Name

Karyopherin alpha 4

Entrez Gene IDs

3840 (Human); 16649 (Mouse); 361959 (Rat)

Alternate Names

Importin alpha 3; Importin alpha Q1; importin subunit alpha-4; importin-alpha-Q1; IPOA3; karyopherin alpha 4 (importin alpha 3); KPNA4; MGC12217; MGC26703; Qip1; QIP12; QIP1Karyopherin subunit alpha-4; SRP3