Human Integrin  beta 6 PE-conjugated Antibody

FAB4155P has been discontinued. View all Integrin beta 6 products.
  (1 citations)     
Datasheet / CoA / SDS
Product Details
Citations (1)
FAQs
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  • Species Reactivity
    Human
  • Specificity
    Detects human Integrin beta 6 in direct ELISAs.
  • Source
    Monoclonal Mouse IgG2B Clone # 437211
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Chinese hamster ovary cell line CHO-derived recombinant human Integrin alpha V beta 6
    Phe31-Val992 (Integrin alpha V) and Gly22-Asn707 (Integrin beta 6)
    Accession # P18564 (Integrin beta 6)
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Phycoerythrin
Product Datasheets

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Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Example
Detection of Integrin  beta 6 in HT‑29 Human Cell Line by Flow Cytometry. HT‑29 human colon adenocarcinoma cell line was stained with Mouse Anti-Human Integrin  beta 6 PE‑conjugated Monoclonal Antibody (Catalog # FAB4155P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: Integrin beta 6

Integrin beta 6 (ITG beta 6) is a 95 kDa member of the Integrin beta family. It forms noncovalent heterodimers with Integrin alpha V and appears on epithelia following injury or inflammation. It activates TGF-beta and assists keratinocyte migration. Human Integrin beta 6 is a type I transmembrane glycoprotein that is 767 amino acids (aa) in length. It contains a 688 aa extracellular domain (ECD) (aa 22-709) that incorporates a 241 aa VWF-A domain. Over aa 22-707, human integrin beta 6 ECD shares 90% and 93% aa sequence identity with mouse and pig integrin beta 6 ECD, respectively.

  • Entrez Gene IDs:
    3694 (Human); 16420 (Mouse); 311061 (Rat)
  • Alternate Names:
    Integrin beta 6; integrin beta-6; integrin, beta 6; ITGB6
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citations: Showing 1 - 1

  1. Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin alphavbeta5-induced secretion of VEGF-A.
    Am. J. Pathol., 2012;181(2):693-705.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow

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