Human Kallikrein 6/Neurosin Alexa Fluor® 750-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Kallikrein 6/Neurosin

Tissue kallikreins are a family of extracellular serine proteases consisting of 15 members (1, 2). The genes of this family aligned in tandem on chromosome 19q13.4 represent the largest contiguous group of proteases within the human genome. Tissue kallikreins have attracted great interest as potential biomarkers for various cancers, including prostate, ovarian, breast, testicular, and lung (2, 3). Human Kallikrein 6 (KLK6) is a member of tissue kallikrein family observed in breast and brain tissues, colon carcinoma cells, and oligodedrocytes (1‑3). Known protein substrates of KLK6 are myelin basic protein, the precursor of the A beta amyloid peptide, and plasminogen. Its physiological functions may include the participation in demyelination processes as well as in the progression of inflammatory disease of the CNS. The level of KLK6 is reduced in brain extracts of Alzheimer patients and increased in serum of patients with ovarian cancer.

Product Datasheets

Related Research Areas

• APP Processing and Amyloid Plaque Formation
• Cancer Biomarkers
• Cell to Cell Adhesion Disassembly During EMT
• Coagulation
• Complement Pathway
• Plasmin/Plasminogen and Kallikrein/Kinin Systems
• Serine Proteases and Regulators