Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human, Mouse

Applications

Validated:

Western Blot, Immunoprecipitation

Cited:

Western Blot, Neutralization, ELISA Development

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 265508
View all Kallikrein 6/Neurosin Primary Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Kallikrein 6/Neurosin
Leu22-Lys244
Accession # Q92876

Specificity

Detects human Kallikrein 6/Neurosin in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) Factor X, recombinant mouse HGFA, rhKLK3, 4, 5, 8, 10, 11, 15, rhThrombin, or rhuPA is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Human Kallikrein 6/Neurosin Antibody

Application
Recommended Usage

Immunoprecipitation

25 µg/mL
Sample: Conditioned cell culture medium spiked with Recombinant Human Kallikrein 6/Neurosin (Catalog # 5164-SE), see our available Western blot detection antibodies

Western Blot

1 µg/mL
Sample: Recombinant Human Kallikrein 6/Neurosin (Catalog # 5164-SE)

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Kallikrein 6/Neurosin

Tissue kallikreins are a family of extracellular serine proteases consisting of 15 members (1, 2). The genes of this family aligned in tandem on chromosome 19q13.4 represent the largest contiguous group of proteases within the human genome. Tissue kallikreins have attracted great interest as potential biomarkers for various cancers, including prostate, ovarian, breast, testicular, and lung (2, 3). Human Kallikrein 6 (KLK6) is a member of tissue kallikrein family observed in breast and brain tissues, colon carcinoma cells, and oligodedrocytes (1‑3). Known protein substrates of KLK6 are myelin basic protein, the precursor of the A beta amyloid peptide, and plasminogen. Its physiological functions may include the participation in demyelination processes as well as in the progression of inflammatory disease of the CNS. The level of KLK6 is reduced in brain extracts of Alzheimer patients and increased in serum of patients with ovarian cancer.

References

  1. Emami, N. and E.P. Diamandis (2007) Clin Chim Acta 381:78.
  2. Borgoño, C.A. and E.P. Diamandis (2004) Nat. Rev. Cancer, 4:876.
  3. Paliouras, M. et al. (2007) Cancer Lett. 249:61.

Alternate Names

KLK6, Neurosin, Protease M, PRSS18, PRSS9, SP59, Zyme

Entrez Gene IDs

5653 (Human)

Gene Symbol

KLK6

UniProt

Q92876

Additional Kallikrein 6/Neurosin Products

Product Documents for Human Kallikrein 6/Neurosin Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

Download SDS

Product Specific Notices for Human Kallikrein 6/Neurosin Antibody

For research use only

Citations for Human Kallikrein 6/Neurosin Antibody

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