Human LAMP-2A/CD107b (NP_002285) VersaClone cDNA

Catalog # Availability Size / Price Qty
RDC0977
R&D Systems VersaClone cDNA Plasmids
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Human LAMP-2A/CD107b (NP_002285) VersaClone cDNA Summary

Specifications

Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Product Datasheets

Background: LAMP-2/CD107b

Lysosomal associated membrane protein 2 (LAMP-2), also known as CD107b and LGP110, is an approximately 110 kDa transmembrane glycoprotein that is a major component of lysosomal membranes. Within the lumenal domain, human LAMP2 shares approximately 64% aa sequence identity with mouse and rat LAMP-2. LAMP-2 itself is subject to lysosomal degradation following cleavage of its lumenal domain. It mediates the lysosomal uptake of the chaperone HSC73 in complex with cargo proteins and is required for the lysosomal destruction of autophagic vacuoles. In cytotoxic T cells and mast cells, LAMP-2 is expressed in the membranes of intracellular granules that contain effector molecules such as perforin, granzymes, eicosanoids, and histamine. Up-regulated LAMP-2 at the plasma membrane serves as an indicator of cell activation of CD8+ T cells, mast cells, monocytes, and platelets. LAMP-2 is a native ligand for lectins Galectin-1 and Galectin-3.

Long Name
Lysosome-associated Membrane Glycoprotein 2
Entrez Gene IDs
3920 (Human); 16784 (Mouse)
Alternate Names
CD107 antigen-like family member B; CD107b antigen; CD107b; LAMP2; LAMP-2; LAMP2A; LAMP-2A; LAMPB; LGP110; LGP-96; Lysosomal Associated Membrane Protein 2 ; lysosomal-associated membrane protein 2; lysosome-associated membrane glycoprotein 2; Lysosome-associated membrane protein 2

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