Human LRRC52 Alexa Fluor™ Plus 405‑conjugated Antibody

R&D Systems | Catalog # FAB10260AFP405

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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Alexa Fluor Plus 405 (Excitation = 404 nm, Emission = 455 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 1037552
View all LRRC52 Primary Antibodies »

Product Specifications

Specificity

Detects human LCCC52 in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human LRRC52 Alexa Fluor™ Plus 405‑conjugated Antibody

Application
Recommended Usage

Flow Cytometry

Optimal dilution of this antibody should be experimentally determined.

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Flow Cytometry

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: LRRC52

LRRC52 (Leucine-rich repeat-containing protein 52) belongs to an extracellular leucine-rich-repeat–only (Elron) cluster, which includes five other LRRC proteins: LRRC26, LRRC38, LRRC55, LRTM1 and LRTM2 (1). Elron cluster members are type I transmembrane proteins with an extracellular domain (ECD) containing several LRR motifs and a cytoplasmic C-terminal tail with a short stretch of acidic residues (1). The mature ECD of LRRC52 is 221 amino acids (aa), containing 5 LRR motifs, and shares 76% and 78% identity with mouse and rat LRRC52, respectively. LRRC-52 is dominantly expressed in testis and skeletal muscle and is also detected in several other tissues including placenta, kidney, lung, and some glands (2, 3). LRRC52 has been identified as a testes specific SLO3 K+ channel accessory protein in mouse (2). LRRC52 is proposed to be essential for alkalization dependent activation of the KSper current at physiological membrane potentials and pH (2). Activation of the SLO3 channel is critical in the fertilization process and loss of function results in infertility (2, 4, 5). A second Elron cluster protein, LRRC26, was recently identified as a regulatory subunit of SLO1 BK-type K+ channels, suggesting a general function for the entire family (6). Based on function, LRRC52 might be a therapeutic target for male contraception (7).

References

  1. Dolan, J. et al. (2007) BMC Genomics 8:320.
  2. Yang, C. et al. (2011) PNAS 108:19419.
  3. Leonetti, M. et al. (2012) PNAS. 109:19274.
  4. Navarro, B. et al. (2007) PNAS 104:7688.
  5. Sanit, C. et al. (2010) FEBS Lett. 584:1041.
  6. Yan, J. and Aldrich, RW. (2010) Nature 466:513.
  7. Zeng, XH. et al. (2015) PNAS 112:2599.

Long Name

Leucine-rich Repeat Containing 52

Alternate Names

BK Channel Auxiliary Gamma Subunit LRRC52

Entrez Gene IDs

440699 (Human); 240899 (Mouse); 289199 (Rat)

Gene Symbol

LRRC52

UniProt

Q8N7C0

Additional LRRC52 Products

Product Documents for Human LRRC52 Alexa Fluor™ Plus 405‑conjugated Antibody

Certificate of Analysis

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Product Specific Notices for Human LRRC52 Alexa Fluor™ Plus 405‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Related Research Areas

Ion Channels and Regulators

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