Human/Mouse/Rat FKBP25 Alexa Fluor® 488-conjugated Antibody

Catalog #: FAB3955G Datasheet / COA / SDS

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FAB3955G-100UG

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Human/Mouse/Rat FKBP25 Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects endogenous human, mouse, and rat FKBP25 in Western blots. In Western blots, this antibody does not cross-react with recombinant human FKBP12, FKBP12.6, FKBP13, FKBP38, FKBP51, or FKBP52.

Source

Monoclonal Rat IgG2b Clone # 423325

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human FKBP25
Ala2-Asp224
Accession # Q00688

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: FKBP25

FK506 binding protein, 25 kDa molecular weight (FKBP25), also called FKBP3, is a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues critical for proper folding of proteins. The macrolide immunosuppressant Rapamycin is a potent inhibitor of FKBP25. FKBP25 is localized in the nucleus, where it alters the activity of histone deacetylases and transcription factors. It is found in many tissues, including brain, thymus, and spleen.

Long Name

25 kDa FK506 Binding Protein

Entrez Gene IDs

2287 (Human); 30795 (Mouse); 299104 (Rat)

Alternate Names

EC 5.2.1.8,25 kDa FK506-binding protein; FK506 binding protein 3, 25kDa; FK506-binding protein 3 (25kD); FK506-binding protein 3; FKBP25; FKBP25,25 kDa FKBP; FKBP3; FKBP-3; Immunophilin FKBP25; peptidyl-prolyl cis-trans isomerase FKBP3; PPIase FKBP3; PPIase; rapamycin binding protein; Rapamycin-selective 25 kDa immunophilin; rotamase; T-cell