Human Rap2B Alexa Fluor® 594-conjugated Antibody

Catalog #: FAB5710T Datasheet / COA / SDS

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FAB5710T-100UG

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Human Rap2B Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Rap2B in Western blots. No cross-reactivity with recombinant human Rap2A is observed.

Source

Monoclonal Mouse IgG2a Clone # 455517

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Rap2B
Met1-Leu183
Accession # P61225

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Rap2B

Rap2B is a member of the small GTPase superfamily and ras family of proteins. Unlike normal ras proteins that have a nontransforming glutamine residue at aa 61, Rap2B has a threonine residue in that position. This change makes the intrinsic GTPase activity for Rap2B lower, thereby allowing it to exist in the activated state for a longer period of time than normal ras proteins. Aggregation of platelets by thrombin results in the activation of Rap2B in a Ca²⁺and PI3 kinase-dependent manner.

Long Name

Ras-related Protein 2B

Entrez Gene IDs

5912 (Human); 74012 (Mouse); 170923 (Rat)

Alternate Names

MGC20484; Rap2B; RAP2B, member of RAS oncogene family; Ras family small GTP binding protein RAP2B; ras-related protein Rap-2b; small GTP binding protein