Siglec-8, also known as SAF, is a transmembrane lectin that is expressed on eosinophils, basophils, and mast cells and shows a binding preference for the carbohydrate 6-O sulfated sLe(x). The functional paralog of human Siglec-8 is known as Siglec-F in mouse. Cross-linking of Siglec-8 inhibits Fc epsilon RI alpha induced mast cell degranulation. It also induces eosinophil apoptosis, an effect which is enhanced by the eosinophil-activating cytokines IL-5, IL-33, and GM-CSF.
Human Siglec-8 (NP_055257) VersaClone cDNA
R&D Systems | Catalog # RDC1496
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Siglec-8
Long Name
Sialic Acid Binding Ig-like Lectin 8
Alternate Names
SAF2, Siglec8, SIGLEC8L
Entrez Gene IDs
27181 (Human)
Gene Symbol
SIGLEC8
UniProt
Additional Siglec-8 Products
Product Documents for Human Siglec-8 (NP_055257) VersaClone cDNA
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Human Siglec-8 (NP_055257) VersaClone cDNA
For research use only
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Associated Pathways
