Human UNC5H3 (NP_003719) VersaClone cDNA

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R&D Systems VersaClone cDNA Plasmids
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Human UNC5H3 (NP_003719) VersaClone cDNA Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: UNC5H3

Members of the UNC5H family are best known as receptors for the axon guidance molecule netrin. Structurally, UNC5Hs have two Ig and two thrombospondin type 1 domains in their extracellular region, and a conserved ZU-5 domain, a deleted in colorectal cancer (DCC)-binding domain, and a C-terminal death domain in their cytoplasmic region. In general, they mediate the chemorepulsive effects of netrin, while the other netrin receptor subtype, DCC, mediates attraction. Members of the UNC5H family have also been implicated as tumor suppressors and regulators of apoptosis.

Long Name
Netrin Receptor UNC5C
Entrez Gene IDs
8633 (Human)
Alternate Names
netrin receptor UNC5C; Protein unc-5 homolog 3; Protein unc-5 homolog C; unc-5 homolog 3; unc-5 homolog C (C. elegans); UNC5C; UNC5H3; UNC5H3unc5 (C.elegans homolog) c

Citation for Human UNC5H3 (NP_003719) VersaClone cDNA

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Netrin-1 receptor UNC5C cleavage by active &delta-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies
    Authors: G Chen, SS Kang, Z Wang, EH Ahn, Y Xia, X Liu, IM Sandoval, FP Manfredsso, Z Zhang, K Ye
    Science Advances, 2021-04-16;7(16):.  2021-04-16


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