Huwentoxin IV

   
Product Datasheet
Catalog Number:4718
Chemical Name:
Product Details
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Biological Activity
Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel by binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration.
Technical Data
  • M.Wt:
    4106.79
  • Formula:
    C174H278N52O51S6
  • Sequence:
    ECLEIFKACNPSNDQCCKSSKLVCSRKTRWCKYQI

    (Modifications: Disulfide bridge: 2-17,9-24,16-31)

    (Modifications: Ile-35 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    526224-73-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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