Catalog Number: 0778
Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
Biological Activity
Highly potent κ agonist, 146-fold more active than U-50488 (Cat. No. 0495) in vitro.
Technical Data
  • M.Wt:
    427.8
  • Formula:
    C21H24Cl2N2O.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    115199-84-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective κ-opioid agonists.
    Barlow et al.
    J.Med.Chem., 1991;34:3149
  2. 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid κ agonists.
    Costello et al.
    J.Med.Chem., 1991;34:181

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